Here is the list of World’s most isolated cities.
Yakutsk is a region in Siberia, Russia that covers more than 1 million square miles but it is extremely isolated. It is home to less than a million people. This means that for every resident there are enough lakes and rivers in the region.
Iquitos in Peru is another isolated place buried deep inside the Amazon jungle. It is surrounded by rainforests. The area has just a single outward road that dead ends in the neighboring place 65 miles away. The residents of the area have to import everything to survive.
Then the whole Greenland country is quite isolated but Ittoqqortoormiit is the most isolated town in the country. It has only 450 residents and just a single grocery store. People survive on fishing and hunting.
A village in South Atlantic is one of the most isolated communities on our Earth. The residents in this town are just 300 and the easiest way to get there is to take a six-day boat ride from South Africa.
In China, Urumqi is the furthest city from the coastline in the world. It is a small place surrounded by desert and mountains.
Located in Australia, Coober Pedy is an isolated place with a population of just 2000. The place has underground shops, bars and churches.
Siwa Oasis in Egypt are surrounded by the Saharan desert and the only way to reach them is by road. Its not completely isolated but the location of the place makes it seem so.